Joerg Heeren Selected Research

Antigens

1/2021	Nanoparticle-mediated targeting of autoantigen peptide to cross-presenting liver sinusoidal endothelial cells protects from CD8 T-cell-driven autoimmune cholangitis.
10/2019	Liver infiltrating T cells regulate bile acid metabolism in experimental cholangitis.
6/2015	Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice.

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Joerg Heeren Research Topics

Disease

20	Insulin Resistance 01/2023 - 02/2008
20	Obesity 01/2022 - 11/2008
11	Atherosclerosis 01/2022 - 03/2006
7	Dyslipidemias (Dyslipidemia) 01/2022 - 03/2006
6	Type 2 Diabetes Mellitus (MODY) 01/2023 - 02/2013
6	Inflammation (Inflammations) 01/2022 - 12/2014
6	Hepatocellular Carcinoma (Hepatoma) 11/2017 - 04/2003
5	Metabolic Diseases (Metabolic Disease) 01/2024 - 05/2013
5	Hypertriglyceridemia 10/2018 - 06/2005
4	Fatty Liver 01/2022 - 01/2015
4	Weight Loss (Weight Reduction) 01/2022 - 01/2013
4	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 05/2008
3	Hypoxia (Hypoxemia) 04/2024 - 01/2021
2	Neoplasm Metastasis (Metastasis) 04/2024 - 01/2014
2	Non-alcoholic Fatty Liver Disease 01/2023 - 01/2021
2	Liver Cirrhosis (Hepatic Cirrhosis) 10/2022 - 10/2021
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022 - 11/2017
2	Hyperlipidemias (Hyperlipidemia) 10/2021 - 07/2005
2	Autoimmune Diseases (Autoimmune Disease) 01/2021 - 06/2015
2	Cholangitis 01/2021 - 10/2019
2	Liver Diseases (Liver Disease) 01/2021 - 10/2019
2	Hyperglycemia 01/2019 - 12/2015
2	Weight Gain 03/2016 - 05/2015
2	Hypercholesterolemia 01/2015 - 09/2010
2	Infections 11/2014 - 01/2013
1	Neoplasms (Cancer) 04/2024
1	Breast Neoplasms (Breast Cancer) 04/2024
1	Mitochondrial Diseases (Mitochondrial Disease) 12/2023
1	Osteoporosis 10/2022
1	Encephalomyelitis (Myeloencephalitis) 01/2021
1	Liver Failure 01/2021
1	Acute Liver Failure (Fulminant Hepatic Failure) 01/2021
1	Liver Neoplasms (Liver Cancer) 10/2020
1	Cholestasis 10/2020
1	Dysbiosis 01/2020
1	Hyperthyroidism 11/2019
1	Atherosclerotic Plaque (Atheroma) 02/2019
1	Multiple Sclerosis 01/2017
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2017

Drug/Important Bio-Agent (IBA)

15	Triglycerides (Triacylglycerol)IBA 01/2023 - 12/2004
13	LipidsIBA 01/2024 - 08/2006
13	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 05/2009
11	Lipoproteins (Lipoprotein)IBA 01/2023 - 12/2004
10	Apolipoproteins E (ApoE)IBA 01/2020 - 04/2003
7	Fatty Acids (Saturated Fatty Acids)IBA 01/2024 - 11/2008
7	Bile Acids and Salts (Bile Acids)IBA 10/2022 - 12/2014
7	ApolipoproteinsIBA 01/2020 - 03/2006
7	Insulin (Novolin)FDA Link 01/2019 - 02/2008
6	CholesterolIBA 10/2020 - 04/2003
4	EnzymesIBA 04/2024 - 01/2017
4	LigandsIBA 01/2021 - 05/2009
4	Proteins (Proteins, Gene)FDA Link 01/2020 - 05/2008
3	LeptinIBA 04/2024 - 05/2009
3	Peptides (Polypeptides)IBA 01/2022 - 06/2015
3	AntigensIBA 01/2021 - 06/2015
3	LDL Receptors (LDL Receptor)IBA 02/2019 - 02/2004
2	Biomarkers (Surrogate Marker)IBA 04/2024 - 01/2016
2	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2024 - 11/2008
2	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2022 - 01/2021
2	AutoantigensIBA 01/2021 - 06/2015
2	Protein Isoforms (Isoforms)IBA 01/2021 - 05/2008
2	HDL CholesterolIBA 01/2018 - 07/2005
2	dimethylaniline monooxygenase (N-oxide forming) (flavin-containing monooxygenase)IBA 01/2017 - 01/2017
2	Amyloid (Amyloid Fibrils)IBA 01/2017 - 05/2008
2	trimethyloxamine (trimethylamine N-oxide)IBA 01/2017 - 01/2017
2	MicroRNAs (MicroRNA)IBA 03/2016 - 02/2013
2	Apolipoprotein A-VIBA 10/2010 - 06/2005
2	Apolipoprotein E4IBA 05/2008 - 12/2004
1	Carbonic Anhydrase IXIBA 04/2024
1	ChylomicronsIBA 12/2023
1	Metformin (Glucophage)FDA LinkGeneric 01/2023
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2022
1	Inosine FDA Link 01/2022
1	Hormones (Hormone)IBA 01/2022
1	NAD (NADH)IBA 10/2021
1	Mixed Function Oxygenases (Monooxygenases)IBA 10/2021
1	Alanine Transaminase (SGPT)IBA 10/2021
1	OxysterolsIBA 10/2021
1	OVA-8IBA 01/2021
1	Acetaminophen (Paracetamol)FDA LinkGeneric 01/2021
1	Purinergic Receptors (Receptors, Purine)IBA 12/2020
1	Inulin FDA Link 10/2020
1	Blood Glucose (Blood Sugar)IBA 01/2020
1	Taurolithocholic AcidIBA 01/2020
1	Long Noncoding RNAIBA 01/2020
1	LDL Lipoproteins (beta Lipoproteins)IBA 02/2019
1	disodium (R,R)- 5- (2- ((2- (3- chlorophenyl)- 2- hydroxyethyl)- amino)propyl)- 1,3- benzodioxole- 2,3- dicarboxylateIBA 02/2019
1	Liver ExtractsIBA 01/2018
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 01/2018
1	Adrenergic Agents (Adrenergic Drugs)IBA 01/2018
1	Ribosomal Protein S6 Kinases (S6 Kinase)IBA 01/2018
1	Antisense OligonucleotidesIBA 01/2017
1	Alprostadil (Muse)FDA LinkGeneric 05/2016
1	fibroblast growth factor 21IBA 03/2016

Therapy/Procedure

3	Therapeutics 01/2022 - 01/2014
1	Fecal Microbiota Transplantation 01/2022
1	Bariatric Surgery 01/2022
1	Gastric Bypass (Roux-en-Y Gastric Bypass) 01/2022
1	Induced Hyperthermia (Thermotherapy) 11/2019
1	Denervation 01/2019